Pharmaceutic agent, method of obtaining same, method of obtaining a complex, complex obtained thereby, method of stabilising such compound, method of transforming a slightly soluble crystaline compound into stable amorphous form thereof and therapeuticall

摘要

Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50 DEG . The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.