发明名称 |
Lipid formulations for nucleic acid delivery |
摘要 |
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP. |
申请公布号 |
US9364435(B2) |
申请公布日期 |
2016.06.14 |
申请号 |
US201414462441 |
申请日期 |
2014.08.18 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
Yaworski Edward;Lam Kieu;Jeffs Lloyd;Palmer Lorne;MacLachlan Ian |
分类号 |
C12N15/11;A61K9/127;A61K48/00;C07H21/00;C07J9/00;C12N15/113 |
主分类号 |
C12N15/11 |
代理机构 |
Kilpatrick Townsend & Stockton LLP |
代理人 |
Kilpatrick Townsend & Stockton LLP |
主权项 |
1. A nucleic acid-lipid particle comprising:
(a) a nucleic acid; (b) a cationic lipid comprising from 50 mol % to 85 mol % of the total lipid present in the particle; (c) a non-cationic lipid comprising from 13 mol % to 49.5 mol % of the total lipid present in the particle; and (d) a conjugated lipid that inhibits aggregation of particles comprising from 0.5 mol % to 2 mol % of the total lipid present in the particle. |
地址 |
Burnaby, BC CA |