AN INTEGRATED MICROFLUIDIC NOZZLE DEVICE FOR CHROMATOGRAPHIC SAMPLE PREPARATION FOR MASS SPECTROMETRY APPLICATIONS

摘要

In accordance with one aspect of the present invention, a low-cost injection-molded plastic microfluidic device that performs the multiplexing of affinity or chromatographic sample cleanup and enrichment methods and the detection by nanospray mass spectrometry of analytes such as biomarkers in a single package to conserve sample, and processes body fluids with HPLC grade and even next- generation chromatographic resins such as nanoparticles to maximize the sensitivity of the detection.