| 主权项 |
1. A method for measuring the in vivo metabolism of SOD1 in a subject, the SOD1 being synthesized in the central nervous system, the method comprising:
(a) administering a labeled moiety to the subject, the labeled moiety being capable of crossing the blood brain barrier and incorporating into SOD1 as the SOD1 is synthesized in the central nervous system of the subject; (b) obtaining at least one biological sample from the subject, the biological sample comprising a SOD1 fraction labeled with the moiety and a SOD1 fraction not labeled with the moiety; and (c) detecting the amount of labeled SOD1 and the amount of unlabeled SOD1, wherein the ratio of labeled SOD1 to unlabeled SOD1 is directly proportional to the metabolism of SOD1 in the subject. |
