Methods and compositions for inhibition of immune responses and autoimmunity

摘要

The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.

主权项

1. A polynucleotide consisting of a nucleotide sequence of the formula: 5′-NnUGCNm-3′, wherein 5′-UGC-3′ is a TLR7-inhibitory sequence located at or 1 nucleotide from the 5′ end of the polynucleotide, each N is a nucleotide, n is 0 or 1, m is an integer from 5 to 50, and Nm comprises 5′-S1S2S3S4-3′, wherein 5′-S1S2S3S4-3′ is a TLR9-inhibitory sequence, at least one of S1, S2, S3, and S4 is inosine, wherein remaining S1, S2, S3, and S4, if any, are G, and wherein the polynucleotide does not comprise a CG dinucleotide.