METHOD AND SYSTEM FOR INDUCING CONTROLLED AND VARIED FLUID STRESSES BY BEAD OSCILLATION

摘要

A method using variable bead-oscillation-based stress parameters, including relative bead dimensionality or other structural features as well as stress duration or intensity or overall magnitude, in inducing different shear stresses in biological samples, for testing the effects of different combinations of various defined stress conditions.

主权项

1. A method of stressing a sample with bead-oscillation while controlling the nature or type of mechanical stress applied, the method comprising:
selecting a sample for subjecting to controlled mechanical stress; selecting an object for oscillation within said sample to create said stress; placing said sample with said object in a container for said oscillation; securing said container such that said sample and said object are enclosed; and causing said oscillation of said object to occur; wherein said oscillation occurs according to predefined stress parameter(s), with at least one of said parameter(s) relating to predetermined effect(s) of said object on flow turbulence and/or laminarity relative to other object(s).