发明名称 |
Immunoassay reagents and method for determining cyclosporine. |
摘要 |
<p>Cyclosporine derivatives useful as detectable tracer compounds for the immunoassay determination of cyclosporine are disclosed. The cyclosporine derivatives comprise a detectable moiety coupled to the amino acid at the first position (MeBmt) in cyclosporine, the second position (Abu) in cyclosporine, the third position (Sar) in cyclosporine, the eighth position (D-Ala) in cyclosporine, or the tenth position (MeLeu) in cyclosporine. A preferred cyclosporine derivative comprises a fluorescent moiety coupled to the hydroxyl group of the amino acid at the first position in cyclosporine, and is especially useful for the fluorescent polarization immunoassay deterimination of cyclosporine. A fluorescent polarization immunoassay method and test kit are also disclosed. <IMAGE></p> |
申请公布号 |
EP0473961(A2) |
申请公布日期 |
1992.03.11 |
申请号 |
EP19910113328 |
申请日期 |
1991.08.08 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MORRISON, MARJORIE A.;MEUCCI, VICTORIA P.;LUNETTA, STEVEN E.;ZAJAC, MARIOLA B.;SIMPSON, ELIZABETH A. |
分类号 |
A61K51/00;C07K7/64;C07K16/00;C12P21/04;G01N33/53;G01N33/533;G01N33/536;G01N33/542 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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