| 摘要 |
PROBLEM TO BE SOLVED: To obtain an optically active (aminoalkyl)-substituted indole derivative, useful as the intermediate for a compound having aβ3 adrenergic acceptor stimulant action, by methathesis of the salt obtained by reacting a specific derivative with a specific acid. SOLUTION: This optically active 3-(2'-aminoalkyl)-7-substituted indole derivative, shown by formula III, is obtained by reacting (A) a (±)-3-(2'-aminoalkyl)-7- substituted indole derivative shown by formula I [R1 is a lower alkyl or aralkyl; and R2 is a (cyclic) lower alkyl] with (B) 0.5 to 1 equivalent of an optically active organic salt shown by the formula A*H in the presence of (C) a solvent to form the salt (D) of the components A and B, shown by formula II [(n) is 0.5 to 1], and then by methathesis of the isolated salt (D). The compounds useful as the component B include a monobasic acid of L-mandelic acid or the like, and dibasic acid of L-ditoluoyl tartrate, the latter being more preferable. |
