Growth blocking agents

摘要

There is disclosed anti-receptor and growth blocking agents to the vitamin B₁₂/transcobalamin II receptor and binding sites. The anti-receptor and growth blocking agents antagonize or modulate the vitamin B₁₂/transcobalamin II receptor or binding sites, causing cellular depletion of vitamin B₁₂, thus inhibiting cell division or causing apoptosis. Anti-receptor and growth blocking agents of the present invention include proteins (such as antibodies and antibody derivatives), peptides and small organic molecules. In a preferred embodiment, the anti-receptor agent is an antibody to the vitamin B₁₂/transcobalamin II receptor.