METHODS TO TREAT AND/OR PREVENT RADIATION- AND/OR CHEMICAL-INDUCED TOXICITY IN NON-MALIGNANT TISSUE

摘要

The present invention relates to methods useful for treating and/ or preventing radiation- and/ or chemical-induced toxicity in non-malignant tissue using a protease activated receptor- 1 (PAR-I) inhibitor. In particular, use of a protease activated receptor- 1 (PAR-I) inhibitor to treat and/or prevent acute and chronic adverse effects of radiation and /or chemical exposure (e.g., to one or more of the following: intestine, lung, oral mucosa, or other organs).