| 发明名称 | Compositions and methods for modulating angiopoietin-like 3 expression | ||
| 摘要 | Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing lipids and/or glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease and/or metabolic disease, or a symptom thereof, in an individual in need thereof. | ||
| 申请公布号 | US9382540(B2) | 申请公布日期 | 2016.07.05 |
| 申请号 | US201514701999 | 申请日期 | 2015.05.01 |
| 申请人 | Isis Pharmaceuticals, Inc | 发明人 | Prakash Thazha P.;Seth Punit P.;Swayze Eric E.;Freier Susan M.;Graham Mark J.;Crooke Rosanne M. |
| 分类号 | C07H21/02;C07H21/04;C12N15/113 | 主分类号 | C07H21/02 |
| 代理机构 | Ionis Patent Department | 代理人 | Ionis Patent Department |
| 主权项 | 1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 contiguous nucleobases complementary to an equal length portion of nucleobases 1140 to 1159 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 80% complementary to SEQ ID NO: 1; and wherein the conjugate group comprises: | ||
| 地址 | Carlsbad CA US | ||