发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 GENE |
摘要 |
PROBLEM TO BE SOLVED: To provide compositions and methods for inhibiting the expression of Eg5 gene.SOLUTION: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.SELECTED DRAWING: None |
申请公布号 |
JP2016214266(A) |
申请公布日期 |
2016.12.22 |
申请号 |
JP20160185278 |
申请日期 |
2016.09.23 |
申请人 |
ALNYLAM PHARMACEUTICALS INC |
发明人 |
BUMCROT DAVID;TAN PAMELA;VORNLOCHER HANS-PETER;GEICK ANKE |
分类号 |
C12N15/113;A61K31/7105;A61K31/713;A61K48/00;A61P35/00;A61P43/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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