| 发明名称 | Delivery of proteins using adeno-associated virus (AAV) vectors | ||
| 摘要 | Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors. | ||
| 申请公布号 | US9527904(B2) | 申请公布日期 | 2016.12.27 |
| 申请号 | US201414484842 | 申请日期 | 2014.09.12 |
| 申请人 | California Institute of Technology | 发明人 | Balazs Alejandro Benjamin;Baltimore David |
| 分类号 | A61K48/00;C07H21/04;C07K16/10;C12N7/00;A01K67/00 | 主分类号 | A61K48/00 |
| 代理机构 | Knobbe Martens Olson & Bear, LLP | 代理人 | Knobbe Martens Olson & Bear, LLP |
| 主权项 | 1. A method for producing a protein of interest in vivo, comprising: providing a recombinant adeno-associated virus (AAV) comprising a promoter operably linked with a nucleotide sequence encoding the protein of interest, wherein the promoter comprises a nucleotide sequence having at least 95% sequence identity to the sequence of SEQ ID NO: 1; and administering the recombinant AAV to a subject, whereby the recombinant AAV expresses the protein of interest in the subject. | ||
| 地址 | Pasadena CA US | ||