发明名称 |
HYALURONIC ACID CONTAINING BIOCONJUGATES : TARGETED DELIVERYOF ANTI-CANCER DRUGS TO CANCER CELLS |
摘要 |
A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule,5 wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one resid ue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof.
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申请公布号 |
CA2445985(A1) |
申请公布日期 |
2002.11.14 |
申请号 |
CA20022445985 |
申请日期 |
2002.05.06 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
LU, ZHENG-RONG;KOPECEK, JINDRICH;LUO, YI;PRESTWICH, GLENN D. |
分类号 |
A61K31/704;A61K31/74;A61K41/00;A61K47/48;(IPC1-7):C08B37/00 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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