| 发明名称 |
MUTEINS OF HUMAN LIPOCALIN 2 (LCN2,HNGAL) WITH AFFINITY FOR GIVEN TARGET |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a protein with high affinity for natural biomolecules such as amyloid beta peptide in Alzheimer's disease or fibronectin extra-domain B, which is associated with tumor neovasculature, and a pharmaceutical composition prepared with the protein.SOLUTION: From a phage display library derived from human lipocalin (Lcn2, hNGAL) with high affinity for natural biomolecules, a mutein with high affinity for amyloid beta peptide or fibronectin extra-domain B is selected.SELECTED DRAWING: None |
| 申请公布号 |
JP2016105709(A) |
申请公布日期 |
2016.06.16 |
| 申请号 |
JP20150236010 |
申请日期 |
2015.12.02 |
| 申请人 |
PIERIS AG |
发明人 |
ARNE SKERRA;MICHAELA GEBAUER;DOMINIK HINZ;SABINE RAUTH;GABRIELE MATSCHINER;MARTIN HUELSMEYER |
| 分类号 |
C12P21/02;A61K38/00;A61P25/28;A61P29/00;A61P35/00;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
C12P21/02 |
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