发明名称 |
Unsolvated crystalline form 1 of N-[5-(3, 5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide and methods of use thereof |
摘要 |
The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H -indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention. |
申请公布号 |
US9382235(B2) |
申请公布日期 |
2016.07.05 |
申请号 |
US201514716986 |
申请日期 |
2015.05.20 |
申请人 |
NERVIANO MEDICAL SCIENCES S.R.L. |
发明人 |
Barbugian Natale Alvaro;Forino Romualdo;Fumagalli Tiziano;Orsini Paolo |
分类号 |
C07D405/12;A61K31/496;C07D405/14 |
主分类号 |
C07D405/12 |
代理机构 |
Scully, Scott, Murphy & Presser, P.C. |
代理人 |
Scully, Scott, Murphy & Presser, P.C. |
主权项 |
1. An unsolvated crystalline form 1 of N-[(3,5-difluorobenzyl)-1H -indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide, wherein said crystalline form is characterized by an x-ray powder diffraction pattern comprising a peak at a 2-theta value of about 4.8±0.5 degrees. |
地址 |
Nerviano (MI) IT |