Mutant-selective EGFR inhibitors and uses thereof

摘要

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

主权项

1. A method for selectively inhibiting at least one mutant of epidermal growth factor receptor (EGFR) as compared to wild-type epidermal growth factor receptor (WT EGFR), in a biological sample or in a patient, comprising contacting the biological sample with, or administering to the patient, a compound of formula I, or a composition thereof: or a pharmaceutically acceptable salt thereof, wherein:
R1 is —CF3 or —Cl;W is —O— or —NH—;R2 is —R or R3 is —R, —C(O)R, or —C(O)OR; andeach R is independently C1-4 alkyl or C1-4 fluoroalkyl.