METHOD FOR PREPARING SILODOSIN AND INTERMEDIATE THEREOF

摘要

Provided is a method for preparing silodosin. Also provided is a method for preparing an organic acid salt of a new intermediate 3-(7-cyano-5-((R)-2-((R)-1-phenylethylamino)propyl)-1-hydrogen-indolyl) propyl alcohol (ester or ether), and a new intermediate 3-(7-cyano-5-((R)-2-(((R)-1-phenethyl)(2-(2-(trifluoroethoxy)phenoxy) ethyl)amino)propyl)1-hydrogen-indolyl)propyl alcohol (ester or ether) and a salt thereof. The method has the following advantages: raw materials are cheap and easy to obtain, the operation is simple, the intermediate and product are easy to purify, the yield is high, and the method is applicable to industrial production.

主权项

1. A compound as represented by formula (I),
Error! Objects Cannot be Created from Editing Field Codes. or a pharmaceutically acceptable salt thereof, wherein, R is selected from H, formyl, aliphatic acyl, substituted or unsubstituted aromatic formyl, tetrahydropyranyl and trialkylsilicyl.