摘要 |
The present application relates to a process for preparation of ceritinib and intermediates thereof. Specifically, the present application relates to a process for preparation of N-(4-(1-benzyl- 1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide (VC) comprising treating N-(4-(bromomethyl)-2-isopropoxy-5-methylphenyl)acetamide (IIID) with 1- benzylpiperidin-4-one (IVA). The present application also relates to a process for conversion of N-(4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)-acetamide (VC) to ceritinib or an acid-addition salt thereof. |
申请人 |
DR. REDDY'S LABORATORIES LIMITED |
发明人 |
MURKI, Veerender;VASAM, Sridhar;KOMATI, Shravan Kumar;GUNDA, Nageshwar;BADISA, Venkata Rao;R, V Ramana Rao;ORUGANTI, Srinivas;GANORKAR, Rakesh;DAHANUKAR, Vilas Hareshwar;KATKAM, Srinivas;THATIPALLI, Poornachander |