ANIMAL MODEL OF NEURODEGENERATIVE DISEASES, METHOD OF OBTAINING SAME AND USES THEREOF

摘要

The non human animal is described as an experimental model for neurodegenerative diseases. This animal model shows an alteration in the biological activity of the IGF-I trophic factor receptor found in the epithelial cells in the choroid plexus of the cerebral ventricles. The described animal model can be obtained through a process of transgenesis. This animal model is useful for the study of ethiopathogenic neurodegenerative diseases, among them those diseases involving dementia, such as Alzheimer, or for the identification and evaluation of therapeutic compounds to combat said diseases.