| 主权项 |
1. A method of treating Parkinson's disease or Lewy body dementia, wherein said method comprises administering to a subject in need thereof a pharmaceutical composition that comprises a therapeutically effective amount of a compound of Formula (A): or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers or diluents; wherein: R1 represents triazolyl or oxadiazolyl, said triazolyl or oxadiazolyl may optionally be substituted with 1 R5 group, X represents N or CH when R1 represents triazolyl or when R1 represents oxadiazolyl X represents CH, R5 represents C1-C6 alkyl, C3-C6 cycloalkyl or a 5-6 membered heterocyclic ring with 1 or 2 heteroatom(s), said cycloalkyl or heterocyclic ring are optionally substituted with 1 or 2 C1-C3 alkyl or 1 or 2 C1-C3 alkoxy, R2, R3 and R4 each independently represents hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, O(CH2)nCF3, (CH2)nR6, (C═O)R6 or (CH2)n(C═O)R6,
n=0, 1, 2 or 3, or R2 and R3 or R3 and R4 may together with the atom they are attached to form a 9-10 membered bicyclic heterocyclic ring with 1 or 2 heteroatom(s), said bicyclic heterocyclic ring may optionally be substituted with 1 or 2 C1-C6 alkyl or 1 or 2 C1-C6 alkoxy, R6 represents a 5-6 membered heterocyclic ring with 1, 2 or 3 heteroatom(s), said heterocyclic ring may optionally be substituted with 1 or 2 C1-C3 alkyl or 1 or 2 C1-C3 alkoxy. |
