METHODS FOR MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES

摘要

PROBLEM TO BE SOLVED: To provide methods or processes allowing cyclic depsipeptides to be obtained with high yields and/or favorable purity.SOLUTION: The invention provides: a method for converting a dehydrate of a compound of a depsipeptide or a salt thereof into a corresponding compound of the formula I or a salt thereof; and a method of synthesis by a combination of solid phase peptide synthesis and solution phase synthesis from corresponding starting amino acids and side chain precursors.SELECTED DRAWING: None