| 发明名称 |
N-maleimidyl polymer derivatives |
| 摘要 |
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives. |
| 申请公布号 |
US9493609(B2) |
申请公布日期 |
2016.11.15 |
| 申请号 |
US201514865362 |
申请日期 |
2015.09.25 |
| 申请人 |
Nektar Therapeutics |
发明人 |
Shen Xiaoming |
| 分类号 |
A61K31/74;C08G65/333;A61K47/48;C08G65/48;C08G65/00 |
主分类号 |
A61K31/74 |
| 代理机构 |
|
代理人 |
Wilson Mark A. |
| 主权项 |
1. A multi-functional N-maleimidyl polymer derivative having the formula: wherein: X is aldehyde; and n is about 20 to about 4000. |
| 地址 |
San Francisco CA US |
