| 发明名称 | Actriia binding agents and uses thereof | ||
| 摘要 | The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIA and uses for same. | ||
| 申请公布号 | US9493556(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414163955 | 申请日期 | 2014.01.24 |
| 申请人 | Acceleron Pharma Inc. | 发明人 | Seehra Jasbir;Martinez-Hackert Erik |
| 分类号 | A61K39/395;C07K16/00;C07K16/18;C07K16/22;C07K16/28 | 主分类号 | A61K39/395 |
| 代理机构 | Ropes & Gray LLP | 代理人 | Ropes & Gray LLP |
| 主权项 | 1. An isolated antibody or fragment thereof that inhibits binding of activin A to human ActRIIA, said isolated antibody or fragment thereof comprising a heavy chain complementarity determining region (CDR-H) 1, CDR-H2, and CDR-H3, and a light chain complementarity determining region (CDR-L) 1, CDR-L2, and CDR-L3 whose amino acid sequences are SEQ ID NOs: 4, 5, 6, 7, 8, and 9, respectively. | ||
| 地址 | Cambridge MA US | ||