| 发明名称 | IL-15 mutants having antagonist activity | ||
| 摘要 | The present invention relates to the identification of an epitope in human Interleukin-15 (IL-15) that is responsible for binding to the interleukin-15 receptor α-chain. Two IL-15 regions are involved in the formation of this epitope: the first region (44LLELQVISL52, peptide 1) corresponds to a sequence located in the B helix and the second (64ENLII68, peptide 2 or 64ENLIIL69, peptide 2a) to a sequence located in helix C. Muteins displaying agonist or antagonist properties are described, and may be useful as therapeutic agents. | ||
| 申请公布号 | US9493533(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201012978115 | 申请日期 | 2010.12.23 |
| 申请人 | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) | 发明人 | Bernard Jérôme;Plet Ariane;Jacques Yannick;Harb Catherine;Quemener Agnès;Mortier Erwan |
| 分类号 | A61K38/20;C07K14/54;C07K7/06;C07K7/08;A61K38/00 | 主分类号 | A61K38/20 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. An IL-15 mutein or fragment thereof, said IL-15 mutein or fragment thereof being characterized in that it has a sequence that is directly derived from human mature wild-type IL-15 by one amino acid substitution of residue 64, 65, 68 or 69, this residue numbering corresponding to the human mature wild-type IL-15, wherein said IL-15 mutein or fragment thereof comprises the mutated 64-69 region, binds to IL-15 Ralpha and is an IL-15 antagonist or an IL-15 partial antagonist. | ||
| 地址 | Paris FR | ||