COMPOSITIONS AND THERAPEUTIC METHODS FOR ACCELERATED PLAQUE REGRESSION

摘要

The invention comprises methods for treating and/or preventing cardiovascular, cholesterol, and lipid related disorders, including atherosclerosis, through-co-administration of therapeutically effective amounts of a compound of Formula I or a pharmaceutically acceptable salt thereof and rosuvastatin or pravastatin or a pharmaceutically acceptable salt of rosuvastatin or pitavastatin. The invention further provides compositions comprising a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of or pitavastatin or a pharmaceutically acceptable salt of rosuvastatin or pitavastatin.

主权项

1. A pharmaceutical composition comprising rosuvastatin or pitavastatin or a pharmaceutically acceptable salt of rosuvastatin or pitavastatin and a compound of Formula I or a pharmaceutically acceptable salt thereof wherein: X is N; Y is CO; R1 and R3 are each independently selected from alkoxy, alkyl, amino, halogen, and hydrogen; R2 is selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, halogen, and hydrogen; R6 and R8 are each independently selected from alkyl, alkoxy, amino, halogen, and hydrogen; R5 and R9 are each hydrogen; R7 is selected from amino, amide, alkyl, hydroxyl, and alkoxy; R10 is hydrogen; each W is independently selected from C and N, wherein if W is N, then p is 0 or 1, and if W is C, then p is 1; for W—(R10)p, W is N and p is 1; for W—(R7)p, W is C and p is 1; for W—(R4)p, W is C, p is 1 and R4 is H, or W is N and p is 0; for (R1)p, p is 1; for (R2)p, p is 1; for (R3)p, p is 1; for (R6)p, p is 1; for (R8)p, p is 1; for (R9)p, p is 1; Z1 is a double bond, and Z2 and Z3 are each a single bond; with the proviso that if R1 is hydrogen, then R3 is alkoxy; with the proviso that if R3 is hydrogen, then R1 is selected from amino and alkoxy; with the proviso that if R7 is selected from alkyl, hydroxyl, and alkoxy, then at least one of R6 and R8 is independently selected from alkyl, alkoxy, amino, and halogen.