发明名称 |
ANTI-PSGL-1 ANTIBODIES AND METHODS OF IDENTIFICATION AND USE |
摘要 |
The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof. |
申请公布号 |
CA2724415(C) |
申请公布日期 |
2016.09.13 |
申请号 |
CA20092724415 |
申请日期 |
2009.05.15 |
申请人 |
SELEXYS PHARMACEUTICALS CORPORATION |
发明人 |
ALVAREZ, RICHARD;ROLLINS, SCOTT |
分类号 |
A61K39/395;C07K16/28;G01N33/566;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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