COMPOSITION AND KITS FOR PSEUDOPLASTIC MICROGEL MATRICES

摘要

This invention relates generally to water-insoluble but water-swellable and deformable crosslinked PEGylated microgel particles of proteins and protein-based macromolecules that are pseudoplastic (shear thinning) and flow in aqueous media under shear and which can be injected or made to flow, wherein said microgel particles can reform as a duster of microgel particles when shearing forces are removed. The microgel particles function as a matrix to support cell growth, viability, and proliferation.

主权项

1. A composition comprising:
a plurality of water-insoluble, hydrogel microparticles comprising PEGylated gel microparticles selected from the group consisting of (1) crosslinked, PEGylated proteins, (2) crosslinked, PEGylated protein-based biological macromolecules, and (3) combinations thereof, wherein said PEGylated hydrogel microparticles comprise a protein or protein-based biological macromolecule crosslinked with a PEGylating agent that is difunctional to multifunctional, wherein, when said plurality of water-insoluble, hydrogel microparticles are hydrated, pseudoplastic.