POPULATION CONTROL USING ENGINEERED TRANSLOCATIONS

摘要

Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.

主权项

1. A method of distributing one or more genes of interest into a population of insects, the method comprising:
providing an insect population, wherein one or more individuals in the insect population comprises a translocation mediated gene drive system; and inducing a chromosomal translocation in the one or more individuals in the insect population, wherein the chromosomal translocation generates a translocation-bearing altered insect population, wherein the translocation-bearing altered insect population comprises translocation-bearing individuals that are translocation heterozygotes and translocation-bearing individuals that are translocation homozygotes for the chromosomal translocation, and wherein the translocation-bearing individuals display a fitness that is greater than that of the wildtype (non-translocation-bearing) individuals when challenged in a condition in which a translocation-based drive occurs.