Compositions and methods for treating inflammation

摘要

Provided are electrokinetically-altered fluids (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating inflammation or at least one symptom thereof. The electrokinetically-altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids (electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.

主权项

1. A method for decreasing inflammatory cytokine levels and/or increasing anti-inflammatory cytokine levels, comprising administering to a subject having inflammation a therapeutically effective amount of an oxygenated ionic aqueous fluid comprising charge-stabilized oxygen gas-containing nanobubbles having an average diameter of less than 100 nanometers sufficient for decreasing inflammatory cytokine levels and/or increasing anti-inflammatory cytokine levels in the subject, wherein the oxygen in the fluid is present in an amount of at least 15 ppm at atmospheric pressure.