| 摘要 |
The invention relates to a recombinant or isolated polypeptide, wherein said polypeptide is or comprises a CD4+ T cell epitope; wherein said polypeptide is no more than 14 amino acids in length; and wherein said polypeptide comprises amino acid sequence selected from the group consisting of KVNFTEIQKL (AFP249-258 = SB94 = SEQ ID NO:4); LQTMKQEFLI (AFP545-554 = SB85 = SEQ ID NO:3); EMTPVNPGV (AFP489-497 = SB44 = SEQ ID NO:5); CLENQLPAFL (AFP86-95 = SB93 = SEQ ID NO:6); SSGEKNIFL (AFP343-351 = SB48 = SEQ ID NO: 8); and variants thereof. The invention also relates to other polypeptides as defined in the claims, and to their uses in the manufacture of medicaments for and treatment of cancer, preferably wherein said cancer expresses alpha fetoprotein, most preferably wherein said cancer is hepatocellular carcinoma (HCC). |
