摘要 |
Provided is a compound of formula (I)[Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/ or lactate dehydrogenase B (LDHB) activity in a cell. |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;VANDERBILT UNIVERSITY |
发明人 |
MALONEY, David J.;JADHAV, Ajit;BANTUKALLU, Ganesha Rai;BRIMACOMBE, Kyle Ryan;MOTT, Bryan T.;YANG, Shyh Ming;URBAN, Daniel Jason;HU, Xin;SIMEONOV, Anton;KOUZNETSOVA, Jennifer L.;WATERSON, Alex Gregory;SULIKOWSKI, Gary Allen;KIM, Kwangho;CHRISTOV, Plamen;JANA, Somnath |