METHODS AND KITS FOR DETERMINING RISK FOR DEVELOPING ALZHEIMER'S DISEASE AND PREVENTION OR TREATMENT THEREOF

摘要

Methods are disclosed for determining a patient's risk for developing Alzheimer's disease and preventing or treating Alzheimer's disease. Kits for assessing a patient's risk of developing Alzheimer's are also provided.

主权项

1. A method for determining a patient's risk of developing Alzheimer's disease, comprising:
obtaining a test sample from the patient; combining the test sample with an intracellular cholesterol staining reagent to form a labeled cholesterol complex; estimating a concentration of intracellular cholesterol in the test sample by quantifying the amount of labeled cholesterol complex in the test sample; and comparing the estimated concentration of intracellular cholesterol in the test sample with a concentration of intracellular cholesterol in a control sample, wherein a greater concentration of intracellular cholesterol in the test sample compared to the control sample indicates an increased risk of developing Alzheimer's disease.