| 发明名称 | PI polyamide | ||
| 摘要 | To provide a safe and stable medicine useful for prevention and treatment of prostate cancer.;A novel PI polyamide is acquired that recognizes and binds to a specific base sequence of an Oct1 gene binding sequence present in a transcriptional regulatory region (AR response region) of an ACSL3 gene and regulating the transcription activity of AR. This leads to the provision of an ACSL3 gene expression inhibitor and a preventive and/or therapeutic agent of prostate cancer containing the PI polyamide as an active ingredient. | ||
| 申请公布号 | US9522978(B2) | 申请公布日期 | 2016.12.20 |
| 申请号 | US201414773631 | 申请日期 | 2014.03.11 |
| 申请人 | NIHON UNIVERSITY | 发明人 | Obinata Daisuke;Takahashi Satoru;Fujiwara Kyoko;Inoue Satoshi;Takayama Kenichi |
| 分类号 | C08G73/20;C07D405/14;C07D403/14;C07D519/00 | 主分类号 | C08G73/20 |
| 代理机构 | Greenblum & Bernstein, P.L.C. | 代理人 | Greenblum & Bernstein, P.L.C. |
| 主权项 | 1. A pyrrole-imidazole polyamide binding to the whole or a part of a base sequence comprising SEQ ID NO:1, the pyrrole-imidazole polyamide being represented by any of the following Formulas 1 to 3: | ||
| 地址 | Tokyo JP | ||