Method of treating an inflammatory condition by administering toll-like 3 receptor antagonists

摘要

Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.

主权项

1. A method of treating an inflammatory condition comprising administering a therapeutically effective amount of an isolated antibody or fragment thereof to a patient in need thereof for a time sufficient to treat or prevent the inflammatory condition, wherein the antibody binds toll-like receptor 3 (TLR3) amino acid residues K416, K418, L440, N441, E442, Y465, N466, K467, Y468, R488, R489, A491, K493, N515, N516, N517, H539, N541, S571, L595, and K619 of SEQ ID NO: 2.