24-HOMO VITAMIN D DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS OBTAINED THEREFROM

摘要

New 24-homo vitamin D derivatives of formula I are described, in which R1 means a hydrogen atom, a hydroxy, an alkanoyloxy group with 1 to 8 carbon atoms or an aralkanoyloxy group with up to 8 carbon atoms, R2 and R3, independently of one another, mean a linear or branched alkyl group with 1 to 4 carbon atoms, a trifluoromethyl group or together mean a saturated carbocyclic ring with 3 to 9 carbon atoms formed with carbon atom 25, R4 and R5, independently of one another, mean a hydrogen atom, an alkanoyl group with 1 to 8 carbon atoms, or an aralkanoyl group with up to 8 carbon atoms, and A and B each mean a hydrogen or together a second bond, and n stands for 1, 2, 3, 4 or 5. A process for production, or these derivatives and pharmaceutical preparations which contain them are also provided. These 24-homo vitamin D derivatives have proliferation-inhibiting and cell-differentiating action.