| 摘要 |
A process for synthesizing a compound of formula (I) is disclosed wherein R represents halo or C1-6 alkyl, unsubstituted or substituted with OP, wherein P represents a protecting group, comprising: (a) reacting a compound of formula (II) with chlorosulfonic acid to produce a compound of formula (III), (b) reacting compound (III) with NHR<a>R<b>, wherein R<a> and R<b> represent H or C1-6 alkyl, to produce a compound of formula (IV), (c) reacting compound (IV) with HNO3 to produce a compound of formula (V), (d) reacting compound (V) with a reducing agent to produce a compound of formula (VI) and (e) reacting compound (VI) with acid to produce a compound of formula (I). Intermediate compounds that are useful in the synthesis of carbapenem side chains are included as well. |
