Nanoemulsion composition containing vitamin K

摘要

In certain embodiments, this invention sets forth compositions, methods, and uses regarding a nanoemulsion composition that comprises a fat-soluble vitamin K and can therapeutically replace Phytonadione Injectable Emulsion, USP.

主权项

1. A transparent or translucent nanoemulsion composition, the composition comprising:
i) vitamin K at about 0.1% to 2% by weight of the nanoemulsion; ii) a phospholipid, wherein the phospholipid is about 4% to about 16% by weight of the nanoemulsion, wherein the phospholipid is a member selected from the group consisting of soy lecithin, egg lecithin and a combination thereof; iii) a triglyceride oil, wherein, the oil concentration is no more than 1% by weight of the nanoemulsion, wherein the oil droplets of said composition have an average diameter of less than 200 nanometers; wherein said transparent or translucent composition exhibits a light transmittance value at 600 nm of no less than 20%, and wherein the composition is free of surfactants of high hydrophobic lipophilic balance value (HLB value >7).