Composition and method for the treatment and prevention of enteric bacterial infections

摘要

The present invention provides a method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.

主权项

1. A composition for use in the treatment or prophylaxis of enteric disease caused by Gram negative bacteria in a human individual, the composition comprising hyperimmune material prepared by immunizing an animal with a vaccine comprising O group serotype antigen, wherein said O antigen is prepared by separation from bacterial cell walls or wall fragments, wherein the O antigen is prepared by subjecting the intact cell walls of gram negative bacteria to shear and separating the O antigen from cell walls of the gram negative bacteria.