发明名称 |
Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
摘要 |
The present invention relates to a combination comprising (5)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, or a pharmaceutically acceptable salt thereof, hereafter “Compound (I)”, and a taxane. Taxanes include established cancer drugs such as docetaxel (Taxotere™) and paclitaxel (Taxol™). Such combinations may be useful in the treatment or prophylaxis of cancer. The invention also relates to a pharmaceutical composition comprising such Compound (I) and a taxane. The invention further relates to a method of treatment comprising the simultaneous, sequential or separate administration of Compound (I) and a taxane, to warm-blooded animal, such as man. The invention also relates to a kit comprising Compound (I) and a taxane, optionally with instructions for use. |
申请公布号 |
US9402847(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201214008459 |
申请日期 |
2012.04.02 |
申请人 |
AstraZeneca AB |
发明人 |
Davies Barry Robert |
分类号 |
A61K31/337;A61K31/519 |
主分类号 |
A61K31/337 |
代理机构 |
|
代理人 |
Kopp Daniel |
主权项 |
1. A method for treating cancer, the method comprising administering to a human or animal in need of such treatment a therapeutically effective amount of (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, in combination with a taxane,
wherein the taxane is dosed prior to (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, and wherein the taxane is only dosed within 1 day prior to a first dosing of the (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide within a given dosage cycle. |
地址 |
Sodertalje SE |