DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES

摘要

Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptides that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPS change selectivity from broad spectrum antimicrobial activity to AMPS with gram-negative selectivity.

主权项

1. An antimicrobial peptide (AMP) comprising an amino acid sequence having at least 90% homology with a peptide selected from the group consisting of:SequenceSEQ ID NO.NH2-FFHHIFRPIVHVGKTIHRLVTG-amide 2NH2-FFHHIFRGKVHVGKTIHRLVTG-amide 3NH2-FFHHIFRGIVHKGKTIHRLVTG-amide 4NH2-FFHHIFRGIVHVKKTIHRLVTG-amide 5NH2-ALWMTLKKKVLKAAAKALNAVLVGANA-amide 7NH2-ALWMTLLKKVLKAKAKALNAVLVGANA-amide 8NH2-ALWMTLKKKVLKAKAKALNAVLVGANA-amide 9NH2-ALWMTLKKKVLKAKAKAALNAVLVGANA-amide12NH2-ALWMTLKKKVLKAKAK-amide13NH2-ALWMTKLKKVLKAKAKALNAVLVGANA-amide14NH2-ALWMTLKKKVLKAKAKALNAVLSGANA-amide15NH2-ALWMTLKKKVLKAKAKALNAVLKGANA-amide16NH2-ALWMTLKKKVLKAKAKALNAVLAGVNA-amide17NH2-ALWMTLKKKVLKAKAKLLNAVLVGANA-amide18NH2-ALWMTLKKKVLKAKAKALNAVLVGLNA-amide19NH2-ALWMTLKKKVLKAKAKLLNAVLVGLNA-amide20 or functional analogues, derivatives or fragments thereof, or a pharmaceutically-acceptable salt thereof.