发明名称 |
NUCLEIC ACID APTAMER CAPABLE OF BONDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR |
摘要 |
[Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. [Solution] A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5'- or 3'-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily. |
申请公布号 |
WO2016158851(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016JP59892 |
申请日期 |
2016.03.28 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD.;THE UNIVERSITY OF TOKYO |
发明人 |
YOSHIMOTO, Keitaro;KIMURA, Keiko;FURUSHO, Hitoshi |
分类号 |
C12N15/115;A61K31/7088;A61K31/711;A61K31/712;A61K31/7125;A61K48/00;A61P3/10;A61P9/00;A61P19/02;A61P29/00;A61P35/00;A61P43/00;C12N15/09;C12Q1/02;C12Q1/68;G01N33/50 |
主分类号 |
C12N15/115 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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