ARTIFICIAL MATCH-TYPE miRNA FOR CONTROLLING GENE EXPRESSION AND USE THEREFOR

摘要

The invention provides an artificial match-type miRNA utilizing miRNA.;A In particular, the invention provides a single strand nucleic acid containing an X region and a Y region, wherein the 3′-terminal of the X region and the 5′-terminal of the Y region are linked via a linker region of a non-nucleotide structure, the X region contains a guide strand sequence of a mature miRNA, and the Y region contains a sequence completely complementary to the X region is an artificial match-type miRNA. The artificial match-type miRNA can suppress expression of the target gene.

主权项

1. An artificial match-type miRNA, which is a single strand nucleic acid comprising X region and Y region,
wherein the 3′-terminal of said X region and the 5′-terminal of said Y region are linked via a linker region of a non-nucleotide structure, said X region comprises a guide strand sequence of a mature miRNA, and said Y region comprises a sequence completely complementary to said X region.