METHOD OF SYNTHESIZING 3-HALO-D-ALANINE METHYL ESTER OR ACID SALT THEREOF

摘要

Disclosed is a method of synthesizing a 3-halo-D-alanine methyl ester or an acid salt thereof. By reacting a D-serine methyl ester or an acid salt thereof and a halogenation reagent in an organic solvent, the method prepares a 3-halo-D-alanine methyl ester or an acid salt thereof. The compound is an important intermediate for preparing a D-cycloserine. The method and process employed in the present invention are easy to operate and highly safe, require a moderate reaction condition, have a high yield, and are low in cost, and reduce waste acid generation considerably and are suitable for industrial production.