Fremgangsmåde til screening af midler til at behandle overvægt

摘要

The invention concerns a method for screening agents capable of treating, by way of prevention or cure, obesity or one of the disorders associated with obesity by modulating the expression of the SPARC protein or of its activity. The invention also concerns a method for diagnosing obesity or one of the disorders associated with obesity by monitoring the expression rate of the SPARC protein or its activity. The invention further concerns a composition comprising an agent modulating the expression of the SPARC protein or its activity. The invention finally concerns the use of any agent modulating the expression of the SPARC protein or its activity for preparing a pharmaceutical composition for treating, by way of prevention or cure, obesity or one of the disorders associated with obesity.