TARGETED CAPSULES FOR THE DELIVERY OF SKIN WHITENING AGENTS IN THE SKIN

摘要

The present invention relates to targeted microcapsules or nanocapsules comprising a skin whitening compound to target melanocytes with a peptide, which is a MC1 receptor agonist, wherein said peptide is coupled to the outer surface of the microcapsule or nanocapsule. It also relates to the use of said microcapsules or nanocapsules for the cosmetic prevention and/or cosmetic treatment of cutaneous dark spots, and to the cosmetic compositions comprising said microcapsules or nanocapsules. The invention also relates to the MC1 receptor agonist peptide coupled to the microcapsule or nanocapsule. The invention also relates to a peptide for use as skin whitening compound.

主权项

1. A microcapsule or nanocapsule comprising a skin whitening compound selected from the group consisting of arbutin, vitamin C, ascorbyl phosphate, niacinamide, dynachondrine, a tyrosinase inhibitor peptide, tretinoin, hydroquinone, kojic acid and esters thereof with fatty acids, azelaic acid, glutathione, cinnamomum subavenium extracts, alpha-hydroxy acids such as lactic acid or glycolic acid, ferulic acid, vitamin E, ellagic acid, Dome grate extracts and mixtures thereof and a peptide of formula (I):(I)R2-Ser1-Tyr2-Ser3-Nle4-Glu5-His6-DPhe7-Arg8-(AA1)9-Gly10-Lys11-DPro12-Val13-R1  wherein R1, is selected from the group consisting of —OH, —OR3, —SR3, —NR3R4, —NHR9, polyethylene glycol or a derivative thereof and —OR9 wherein R9 is polyethylene glycol or a derivative thereof; R2, is selected from the group consisting of H—, R3—C(O)— and R3—OC(O)—, R3 and R4 are independently selected from H, C1-C24 alkyl, C2-C24 alkenyl and C6-C10 aryl; AA1, is selected from the amino acid groups that represents an aromatic amino acid group; and cosmetically acceptable salts and solvates thereof, coupled to the outer surface of the microcapsule or nanocapsule.