Marker for response to antidepressant therapy

摘要

The invention relates to the use of ApoA4 as biomarker for predicting whether a patient will respond to antidepressant treatment. The invention further relates to methods and kits for predicting whether a patient will respond to antidepressant treatment using said biomarker.

主权项

1. A method for predicting whether a patient will respond to antidepressant treatment and treating the patient, comprising:
(a) obtaining a biological sample from the patient; (b) quantifying the amount of ApoA-IV in the biological sample; (c) comparing the amount of ApoA-IV in the biological sample with the amount of ApoA-IV present in one or more reference samples obtained from one or more responders to antidepressant treatment and/or one or more reference samples obtained from one or more non-responders to antidepressant treatment, and identifying the patient as a responder to antidepressant treatment if:
(i) the level of ApoA-IV in the biological sample is equivalent to the level of ApoA-IV in the one or more reference samples from the one or more responders; or(ii) the level of ApoA-IV in the biological sample is lower than the level of ApoA-IV in the one or more reference samples from the one or more non-responders, and (d) administering an anti-depressant to the patient identified as a responder patient.