Host cell modification with artificial endosymbionts

摘要

The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell. The secreted polypeptide can be a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an effector molecule or other factors that can produce a phenotype in the host cell.

主权项

1. An isolated host cell comprising an artificial endosymbiont, wherein the artificial endosymbiont secretes a heterologous protein into the host cell and thereby provides a phenotype to the host cell.