Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a-CD5- or CD34+CD7+CD1a-CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
申请公布号
WO2010051634(A1)
申请公布日期
2010.05.14
申请号
WO2009CA01601
申请日期
2009.11.06
申请人
SUNNYBROOK HEALTH SCIENCES CENTRE;ZUNIGA-PFLUECKER, JUAN, CARLOS;AWONG, GENEVE;LA MOTTE-MOHS, ROSS
发明人
ZUNIGA-PFLUECKER, JUAN, CARLOS;AWONG, GENEVE;LA MOTTE-MOHS, ROSS