RECEPTOR TARGETING CONSTRUCTS AND USES THEREOF

摘要

Disclosed herein are drug delivery molecules that comprise a ligand that targets a cell surface molecule; a membrane penetration domain; and a payload binding domain; and pharmaceutical compositions comprising the same. Also disclosed are methods of treating cancer, inhibiting the progression of cancer, preventing cancer metastasis, and delivering a therapeutic compound to the brain in a subject in need thereof, the methods comprising identifying a subject in need thereof; providing a composition comprising the drug delivery molecule as disclosed herein; and administering an effective amount of the composition to the subject.

主权项

1. A drug delivery molecule, comprising:
a ligand that targets a cell surface molecule; a membrane penetration domain; and a payload binding domain.